Will Wales continue their winning run, or will Eddie Jones' England remain on course for a third Six Nations title in four years? Here's what a few of the experts have had to say.
STUART BARNES: "Cardiff is not a city that intimidates any more. England will miss Mako Vunipola and Maro Itoje but Wales will miss the running power of Taulupe Faletau even more."
SIR CLIVE WOODWARD: "This could be a classic in Cardiff," says Woodward. "The winner will wake up tomorrow morning and realise they are set for a special World Cup year while the losers will look beatable in the eyes of all future opponents.
"Wales are on an amazing 11-match unbeaten run and England have had a huge bounce-back from 2018 and both are led by excellent coaches playing themselves into contention for the World Cup. Both could win that tournament, so this is set up perfectly."
SAM WARBURTON: "Even though I think it is a one-off game, I suspect England's run will just give them the confidence to win away from home.
"I actually think England will sneak it by two points."
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JAMIE ROBERTS: "I really want the lads to go out and make history this weekend.
"That’s not just about the Six Nations, it’s about earning the longest unbeaten run in Welsh rugby history – that is a huge statement in a World Cup year.
"I’m going Wales by two. It might even be a one-point game."
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