Can England make it three on the spin and which game will prove key to Irish hopes?
Rugby experts have been making their predictions for the tournament and here's how they envisage the final table will look.
RUCK POLL:
ANDY NICOL - 1. England, 2. Ireland, 3. Scotland, 4. France 5.Wales, 6. Italy
BEN KAY - 1. England 2. Ireland 3. France 4. Scotland 5.Wales 6.Italy
BRIAN MOORE - 1. Ireland 2. England 3. Wales 4. Scotland 5. France 6. Italy
PAUL O'CONNELL - 1. Ireland 2. England 3. Scotland 4.Wales 5. France 6. Italy
JEREMY GUSCOTT - 1. Ireland 2. England 3. Scotland 4.Wales 5. France 6. Italy
JONATHAN DAVIES - 1. Ireland 2. England 3. Wales 4. Scotland 5. France 6. Italy
SIR IAN MCGEECHAN - 1. England 2. Ireland 3. Scotland 4, Wales 5.France, 6. Italy
MORE STORIES:
STUART BARNES - 1. Ireland 2. England 3. Wales 4. Scotland 5. France 6. Italy
SHANE WILLIAMS - 1. England, 2. Ireland, 3. Wales, 4. Scotland, 5. France, 6. Italy
RUCK - 1. England, 2. Ireland, 3. Scotland, 4, Wales, 5.France, 6. Italy
VOTE FOR YOU ALL-TIME SIX NATIONS XV