Here, we list five players England head coach Steve Borthwick could call-up following the dismal defeat against Scotland on Saturday.
#1. Tom Pearson (London Irish)
Pearson joined the London Irish Senior Academy following his time at Cardiff Metropolitan University.
The back-row forward made 28 BUCS Super Rugby appearances, 14 Welsh Championship appearances and was named in the BUCS Super Rugby Team of the Year during his time in Wales.
Pearson made a creditable impression in his first season with Irish, making 19 appearances for the first team alone with three tries.
In his first team debut, Pearson made the most tackles in Round 6 of the Gallagher Premiership (25) and contributed to the Club's first win that season over Exeter Chiefs at Sandy Park.
He made the most tackle breaks (26) and offloads (8) in Irish's forward players in the 2021/22 Premiership, with his 59 defensive ruck arrivals in the top five amongst the Exiles pack that year.
England came calling for Pearson after an impressive start to life in west London, playing his part in several training camps throughout the 2021/22 year.
The Rugby Players' Association nominated Pearson for their 15 Under-23 MVP of the Month for November 2021, and was included in the organisation's Under-23 Team of the Season alongside teammate Ollie Hassell-Collins.
The youngster was also credited with the James Naughton Memorial Trophy for the Young Player of the Year at the 2022 London Irish Academy Golf Day.
To cap off a sensational year, Pearson was one of six Senior Academy players promoted to the first team set-up under Declan Kidney's staff ahead of the 2022/23 season.
Try celebrations for Tom Pearson of London Irish as he dives over to score during the Gallagher Premiership match between London Irish and Harlequins at The Gtech Community Stadium, London on 29 January 2023 (Photo: Danny Loo/PPAUK)
#2. Ruan Ackermann (Gloucester)
Ackermann, who qualifies for England on residency signed with Gloucester Rugby in the summer of 2017, joining the club from the Lions' Super Rugby squad in South Africa.
Since joining the Cherry and Whites, Ackermann has impressed through his physicality and work rate in each season since coming to Kingsholm and often tops the stats for the most carries in a game.
Playing in 20 of Gloucester Rugby’s 23 games in the 2020-21 season, Ackermann has made the No.8 shirt his own and has enjoyed playing some consistent rugby in the Premiership and European Cup.
Ackermann was called up to the Barbarians squad in the summer of 2016, playing against Samoa at the London Olympic Stadium and is now qualified to play for England through residency.
Try Celebrations for Ruan Ackermann of Gloucester Rugby during the Premiership Rugby Cup match between Gloucester Rugby and Bath Rugby at Kingsholm Stadium on 12 November 2021 in Gloucester, England. (Photo by Tom Sandberg/PPAUK)
#3. Joe Marler (Harlequins)
On the international stage, Marler captained England at U18 level and went on to represented England U20s and the Saxons.
At 23 he was selected for the Senior England side for the series against Argentina and soon became a regular selection, playing 14 consecutive matches for England prior to him taking time off for the birth of his first son. Marler won his 50th cap for his country against Scotland in the successful 2017 RBS Six Nations campaign.
In 2017, Marler - along with fellow Quin Kyle Sinckler - was named in the British and Irish Lions' squad to tour New Zealand.
In the autumn of 2019 Marler came out of international retirement, winning a place in Eddie Jones' England squad who reached the World Cup Final in Japan.
Marler won his 200th cap for Harlequins in January 2020 and the following season was named Man of the Match in the Premiership Final.
Joe Marler of England Rugby during the Six Nations Championship match between England and Wales at Twickenham Stadium, Twickenham, London on February 26th 2021. - PHOTO: Phil Mingo/PPAUK
#4. Raffi Quirke (Sale Sharks)
The Manchester born scrum half started playing rugby when he was just five, inspired by his father Saul, who coached him throughout those early years.
That evidently paid off, with Raffi part of a Broughton Park Rugby Club side that went unbeaten and scoffed 267 tries at U9s level.
Even in his youth Quirke was no stranger to elite competition having won the North-West Triathlon Championship at just 13-years-old. He gave up the sport shortly after to focus solely on rugby affairs and was rewarded for that endeavour, going on to represent England at both U16, U18 and U20 levels.
After signing for Sale in 2018 Raffi spent time honing his skills with help from teammate Faf De Klerk and it has clearly paid dividends.
His performances for club warranted a call up from Eddie Jones in September 2021 for the Autumn Internationals and he hasn’t looked back since.
Sale Sharks player Raffi Quirke during the Gallagher Premiership Rugby Match between Wasps and Sale Sharks at Ricoh Arena on 27 Mar. Photo: Steve Bond/PPAUK
#5. Jonathan Joseph (Bath Rugby)
Joseph joined Bath Rugby in 2013 from London Irish and provided some outstanding moments in Blue, Black and White.
A natural leader and one of the best defensive outside centres in the game, he is not short of speed, agility and awareness - the latter shown on various occasions throughout his career, most recently in 2021/22 setting up two Max Ojomoh tries with a dink from the outside of his right boot.
His dedication to the Blue, Black and Whites has seen him make over 150 appearances for the club, marking the occasion with a special victory of Harlequins.
On the international stage, Joseph has represented England over 50 times and was member of the British & Irish Lions touring party as they drew the 2017 series with New Zealand.
Tom Doughty of Bath Rugby and Jonathan Joseph of Bath Rugby celebrates after winning during the Gallagher Premiership Rugby Match between Bath Rugby and Leicester Tigers at the Recreation Ground on 11 November 2022. Photo: Tom Sandberg/PPAUK